{"id":1002,"date":"2025-08-22T15:14:37","date_gmt":"2025-08-22T15:14:37","guid":{"rendered":"https:\/\/site-cfb:8890\/?page_id=1002"},"modified":"2025-08-22T15:58:09","modified_gmt":"2025-08-22T15:58:09","slug":"recherche","status":"publish","type":"page","link":"https:\/\/www.baclesse.lu\/de\/recherche\/","title":{"rendered":"Forschung"},"content":{"rendered":"

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Recherche<\/p>\n

[\/et_pb_text][et_pb_image src=\u00a0\u00bbhttps:\/\/www.baclesse.lu\/wp-content\/uploads\/2025\/08\/Rayon_CFB_Bleu_Clair_V2.png\u00a0\u00bb title_text=\u00a0\u00bbRayon_CFB_Bleu_Clair_V2″ align_tablet=\u00a0\u00bbleft\u00a0\u00bb align_last_edited=\u00a0\u00bboff|tablet\u00a0\u00bb disabled_on=\u00a0\u00bboff|off|off\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbd6084e7c-e5e7-4196-9a1d-c82dec5ca1d3″ transform_scale_tablet=\u00a0\u00bb80%|80%\u00a0\u00bb transform_scale_phone=\u00a0\u00bb80%|80%\u00a0\u00bb transform_scale_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb transform_translate_tablet=\u00a0\u00bb\u00a0\u00bb transform_translate_phone=\u00a0\u00bb\u00a0\u00bb transform_translate_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb transform_rotate_tablet=\u00a0\u00bb\u00a0\u00bb transform_rotate_phone=\u00a0\u00bb\u00a0\u00bb transform_rotate_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb transform_skew_tablet=\u00a0\u00bb\u00a0\u00bb transform_skew_phone=\u00a0\u00bb\u00a0\u00bb transform_skew_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb transform_origin_tablet=\u00a0\u00bb\u00a0\u00bb transform_origin_phone=\u00a0\u00bb\u00a0\u00bb transform_origin_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb transform_styles_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb custom_margin_tablet=\u00a0\u00bb|8px|||false|false\u00a0\u00bb custom_margin_phone=\u00a0\u00bb|-35px|||false|false\u00a0\u00bb custom_margin_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding_last_edited=\u00a0\u00bboff|tablet\u00a0\u00bb hover_enabled=\u00a0\u00bb0″ transform_styles_tablet=\u00a0\u00bb\u00a0\u00bb transform_styles_phone=\u00a0\u00bb\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb theme_builder_area=\u00a0\u00bbpost_content\u00a0\u00bb sticky_enabled=\u00a0\u00bb0″][\/et_pb_image][et_pb_text _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbd6f57796-6fc7-4376-8cad-9f96836f9966″ hover_enabled=\u00a0\u00bb0″ text_orientation_tablet=\u00a0\u00bb\u00a0\u00bb text_orientation_phone=\u00a0\u00bbleft\u00a0\u00bb text_orientation_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb theme_builder_area=\u00a0\u00bbpost_content\u00a0\u00bb sticky_enabled=\u00a0\u00bb0″]<\/p>\n

Le CFB souhaite aller encore plus loin dans l\u2019accompagnement des patients et leur permettre de mieux vivre leur parcours de soin, pendant et apr\u00e8s le traitement de radioth\u00e9rapie.<\/span><\/p>\n

En vue d\u2019am\u00e9liorer l’efficacit\u00e9 de la radioth\u00e9rapie tout en limitant les effets secondaires (ou toxicit\u00e9s), il d\u00e9veloppe et participe \u00e0 de nombreux projets de recherche, nationaux et internationaux<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb2_3″ module_class=\u00a0\u00bbta-col-droite\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb theme_builder_area=\u00a0\u00bbpost_content\u00a0\u00bb][et_pb_accordion _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbb2d7393e-bc81-42e0-a0ce-26b02b0d4a30″ custom_padding_phone=\u00a0\u00bb30px|0px|18px|0px|false|false\u00a0\u00bb hover_enabled=\u00a0\u00bb0″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb theme_builder_area=\u00a0\u00bbpost_content\u00a0\u00bb sticky_enabled=\u00a0\u00bb0″][et_pb_accordion_item title=\u00a0\u00bbRECHERCHE FONDAMENTALE\u00a0\u00bb open=\u00a0\u00bboff\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bb5629a32d-3e9f-4ba5-abd8-c7ddd780f24f\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb10px||18px|0px|false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb0px||||false|false\u00a0\u00bb hover_enabled=\u00a0\u00bb0″ border_width_all=\u00a0\u00bb0px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb theme_builder_area=\u00a0\u00bbpost_content\u00a0\u00bb sticky_enabled=\u00a0\u00bb0″]<\/p>\n

La Recherche est un domaine cher \u00e0 notre directeur, le Professeur Guillaume Vogin, qui a lui-m\u00eame \u00e9t\u00e9 nomm\u00e9 \u00ab\u00a0clinicien-scientifique affili\u00e9\u00a0\u00bb au Luxembourg Institute of Health (LIH) dans le but de d\u00e9velopper un programme de recherche ax\u00e9 sur les m\u00e9canismes de toxicit\u00e9 induite par la radioth\u00e9rapie.<\/p>\n

Les recherches du Professeur Vogin comprendront des \u00e9tudes mol\u00e9culaires de la radio-toxicit\u00e9 ainsi que des \u00e9tudes cliniques visant \u00e0 am\u00e9liorer l\u2019efficacit\u00e9 de la radioth\u00e9rapie tout en limitant les effets secondaires. En effet, le programme de recherche envisage d\u2019int\u00e9grer les donn\u00e9es d\u2019imagerie quantitative avec une approche radiomique dans le diagnostic et le suivi des s\u00e9quelles. Les \u00e9tudes rechercheront d\u2019autres biomarqueurs individuels de radiosensibilit\u00e9 en utilisant de nouvelles voies de recherche d\u00e9velopp\u00e9es au LIH.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=\u00a0\u00bbRECHERCHE CLINIQUE\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bb5629a32d-3e9f-4ba5-abd8-c7ddd780f24f\u00a0\u00bb hover_enabled=\u00a0\u00bb0″ border_color_top=\u00a0\u00bb#c15fb4″ border_width_right=\u00a0\u00bb0px\u00a0\u00bb border_width_left=\u00a0\u00bb0px\u00a0\u00bb border_color_left=\u00a0\u00bb#c15fb4″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb theme_builder_area=\u00a0\u00bbpost_content\u00a0\u00bb open=\u00a0\u00bboff\u00a0\u00bb sticky_enabled=\u00a0\u00bb0″]Des essais cliniques innovants, notamment dans le traitement des cancers de la\u00a0prostate, du sein et du cerveau, sont \u00e9galement men\u00e9s en partenariat avec des organismes de recherche et des universit\u00e9s de la Grande R\u00e9gion dans le but de faire avancer les connaissances et optimiser les traitements de nos patients.<\/p>\n

D\u00e9couvrez tous nos projets et essais cliniques en cours.<\/h2>\n

APRILUX<\/span>
\nLa soci\u00e9t\u00e9 Neolys Diagnostics en collaboration avec le Prof. Vogin\u00a0ont d\u00e9velopp\u00e9 un test de sensibilit\u00e9 aux rayons appel\u00e9 \u00ab\u00a0RADIODTECT\u00a0\u00bb permettant, \u00e0 l\u2019aide d\u2019une prise de sang, de d\u00e9tecter chez les patients un risque potentiel de d\u00e9velopper des toxicit\u00e9s. Gr\u00e2ce au soutien de la Fondation Cancer, le CFB est en mesure de proposer ce test aux patients dans le cadre de l\u2019\u00e9tude clinique APRILUX. Portant sur 200 patients cons\u00e9cutifs ayant re\u00e7u une indication de radioth\u00e9rapie curative au CFB, elle permettra d\u2019observer la s\u00e9v\u00e9rit\u00e9 des effets secondaires d\u00e9crits par les patients et d\u2019\u00e9valuer les capacit\u00e9s pr\u00e9dictives du test sanguin.<\/p>\n

PART<\/span>
\nPART est une \u00e9tude de phase 2 (test d\u2019efficacit\u00e9 et de s\u00e9curit\u00e9) lanc\u00e9e en 2022 et portant sur l\u2019irradiation s\u00e9lective des ganglions lymphatiques r\u00e9tro-p\u00e9riton\u00e9aux chez les patients porteurs d\u2019un cancer de la prostate pN1. Son but est d\u2019\u00e9valuer si l\u2019irradiation d\u2019un volume plus grand des ganglions lymphatiques du bassin ET des ganglions lymphatiques para-aortiques donne de meilleures chances de gu\u00e9rison et moins de r\u00e9cidives que l\u2019irradiation uniquement des ganglions lymphatiques du bassin.<\/p>\n

INOTREM<\/span>
\nCette \u00e9tude pilote men\u00e9e depuis 2022 par le CFB et la soci\u00e9t\u00e9 INOTREM (soci\u00e9t\u00e9 sp\u00e9cialis\u00e9e dans l\u2019immunoth\u00e9rapie des syndromes inflammatoires aigus), s\u2019int\u00e9resse \u00e0 la valeur pr\u00e9dictive de l\u2019expression et l\u2019activation TREM1 dans l\u2019inflammation et la fibrose mammaire radio-induite. Cette \u00e9tude, men\u00e9e en collaboration avec l\u2019IBBL (pour la gestion d\u2019\u00e9chantillons), a \u00e9t\u00e9 d\u00e9ploy\u00e9 sur plusieurs sites en France (ICL et CHR de Metz) et au CFB.<\/p>\n

Au CFB, les toxicit\u00e9s radio-induites sont suivies \u00e0 court et \u00e0 long terme\u00a0\u00e0 travers des projets comme \u00ab\u00a0CK Boost pelvien (prostate)\u00a0\u00bb, \u00ab\u00a0IMRT Sein\u00a0\u00bb. Les donn\u00e9es r\u00e9colt\u00e9es, actuellement en cours d\u2019analyse, permettront de comprendre l\u2019apparition de ces toxicit\u00e9s et de les pr\u00e9venir.[\/et_pb_accordion_item][et_pb_accordion_item title=\u00a0\u00bbPUBLICATIONS SCIENTIFIQUES\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bb5629a32d-3e9f-4ba5-abd8-c7ddd780f24f\u00a0\u00bb hover_enabled=\u00a0\u00bb0″ border_color_all=\u00a0\u00bbRGBA(255,255,255,0)\u00a0\u00bb border_color_top=\u00a0\u00bb#c15fb4″ border_width_right=\u00a0\u00bb0px\u00a0\u00bb border_color_bottom=\u00a0\u00bb#07bbff\u00a0\u00bb border_width_left=\u00a0\u00bb0px\u00a0\u00bb border_color_left=\u00a0\u00bbRGBA(255,255,255,0)\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb theme_builder_area=\u00a0\u00bbpost_content\u00a0\u00bb open=\u00a0\u00bbon\u00a0\u00bb sticky_enabled=\u00a0\u00bb0″]Nos m\u00e9decins sont particuli\u00e8rement impliqu\u00e9s dans la Recherche et partagent r\u00e9guli\u00e8rement leurs connaissances et leurs r\u00e9sultats \u00e0 travers des publications scientifiques.<\/p>\n

Nos publications<\/h2>\n

Outcome analysis of HDR compared to PDR IGABT in locally advanced cervical cancer: a single-center cohort analysis<\/span><\/p>\n

Johanne Hermesse,\u00a0Cl\u00e9mence Pleyers,\u00a0Christine Gennigens,\u00a0Marjolein De Cuypere,\u00a0Pierre Lovinfosse,\u00a0Laurence Seidel Statistician,\u00a0Philippe Coucke,\u00a0Fr\u00e9d\u00e9ric Kridelka<\/p>\n

Strahlenther Onkol.\u00a02023 Feb;199(2):141-148. doi: 10.1007\/s00066-022-01982-7.\u00a0Epub 2022 Aug 9.<\/p>\n

En savoir plus<\/a><\/p>\n

\n

Stereotactic focal radiotherapy as an alternative treatment for low-risk prostate cancer: results of a single-arm monocenter Phase-II trial<\/span><\/p>\n

Paul V. Nguyen 1,2*, Bertrand Donneaux 2, C\u00e9line Louis 2, Szusa Bodgal 2, Sven Philippi 2, Sylvie Biver 2, B\u00e9rang\u00e8re Fr\u00e9d\u00e9rique 2, Ludovic Harz\u00e9 2, Yves Lasar 3, Guillaume Vogin 2, Philippe Nickers2,4<\/p>\n

Frontiers in oncology<\/p>\n

En savoir plus<\/a><\/p>\n

\n

Could conventionally fractionated radiation therapy coupled with stereotactic body radiation therapy improve local control in bone oligometastases?<\/span><\/p>\n

Py JF, Salleron J, Vogin G, Courrech F, Teixeira P, Colnat-Coulbois S, Baumard F, Thureau S, Supiot S, Peiffert D, Oldrini G, Faivre JC.<\/p>\n

Cancer Radiother. 2023 Feb;27(1):1-10. doi: 10.1016\/j.canrad.2022.03.002. Epub 2023 Jan 12.<\/p>\n

PMID: 36641333<\/p>\n

En savoir plus<\/a><\/p>\n

\n

The Normal, the Radiosensitive, and the Ataxic in the Era of Precision Radiotherapy: A Narrative Review.<\/span><\/p>\n

Pereira S, Orlandi E, Deneuve S, Barcellini A, Chalaszczyk A, Behm-Ansmant I, Hettal L, Rancati T, Vogin G, Thariat J.<\/p>\n

Cancers (Basel). 2022 Dec 19;14(24):6252. doi: 10.3390\/cancers14246252.<\/p>\n

PMID: 36551737 Free PMC article. Review.<\/p>\n

En savoir plus<\/a><\/p>\n

\n

Target volume delineation for radiotherapy of meningiomas: an ANOCEF consensus guideline.<\/span><\/p>\n

Martz N, Salleron J, Dhermain F, Vogin G, Daisne JF, Mouttet-Audouard R, Tanguy R, Noel G, Peyre M, Lecouillard I, Jacob J, Attal J, Charissoux M, Veresezan O, Hanzen C, Huchet A, Latorzeff I, Coutte A, Doyen J, Stefan D, Feuvret L, Garcia GCTE, Royer P.<\/p>\n

Radiat Oncol. 2023 Jul 5;18(1):113. doi: 10.1186\/s13014-023-02300-w.<\/p>\n

PMID: 37408055 Free PMC article. Review.<\/p>\n

En savoir plus<\/a><\/p>\n

\n

Lighting Up the Fire in the Microenvironment of Cold Tumors: A Major Challenge to Improve Cancer Immunotherapy.<\/span><\/p>\n

Benoit A, Vogin G, Duhem C, Berchem G, Janji B.<\/p>\n

Cells. 2023 Jul 5;12(13):1787. doi: 10.3390\/cells12131787.<\/p>\n

PMID: 37443821 Free PMC article. Review.<\/p>\n

En savoir plus<\/a><\/p>\n

\n

Multicentric development and evaluation of\u00a018F-FDG PET\/CT and MRI radiomics models to predict para-aortic lymph node involvement in locally advanced cervical cancer.<\/span><\/p>\n

Lucia F, Bourbonne V, Pleyers C, Dupr\u00e9 PF, Miranda O, Visvikis D, Pradier O, Abgral R, Mervoyer A, Classe JM, Rousseau C, Vos W,\u00a0Hermesse J, Gennigens C, De Cuypere M, Kridelka F, Schick U, Hatt M, Hustinx R, Lovinfosse P.<\/p>\n

Eur J Nucl Med Mol Imaging. 2023 Jul;50(8):2514-2528. doi: 10.1007\/s00259-023-06180-w. Epub 2023 Mar 9.PMID:\u00a036892667<\/p>\n

En savoir plus<\/a>[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

RechercheLe CFB souhaite aller encore plus loin dans l\u2019accompagnement des patients et leur permettre de mieux vivre leur parcours de soin, pendant et apr\u00e8s le traitement de radioth\u00e9rapie. En vue d\u2019am\u00e9liorer l’efficacit\u00e9 de la radioth\u00e9rapie tout en limitant les effets secondaires (ou toxicit\u00e9s), il d\u00e9veloppe et participe \u00e0 de nombreux projets de recherche, nationaux et […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-1002","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nRecherche - Centre Fran\u00e7ois Baclesse<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.baclesse.lu\/de\/recherche\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Recherche - Centre Fran\u00e7ois Baclesse\" \/>\n<meta property=\"og:description\" content=\"RechercheLe CFB souhaite aller encore plus loin dans l\u2019accompagnement des patients et leur permettre de mieux vivre leur parcours de soin, pendant et apr\u00e8s le traitement de radioth\u00e9rapie. 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